Dr. Değirmenci Uzun graduated from Middle East Technical University in 2010. She then received her MSc degree from Koc University in 2012. She obtained her PhD degree at University of Zurich in 2018. During her PhD thesis, she identified the essential Wnt–secreting stem cell niche in the intestine and characterized its roles during homeostasis, regeneration and cancer. She could achieve first author publications in the journals Cell Reports and Nature. She aims to identify the role of stem cell niche in pathological situations.
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Degirmenci, B., Dincer, C., Demirel, H. C., Berkova, L., Moor, A. E., Kahraman, A., Hausmann, G., Aguet, M., Tuncbag, N., Valenta, T., & Basler, K. (2021). Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model. iScience, 24(12), 103369.
Degirmenci, B., Valenta, T., Dimitrieva, S., Hausmann, G., & Basler, K. (2018). GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells. Nature, 558(7710), 449–453.
Degirmenci, B., Hausmann, G., Valenta, T., & Basler, K. (2018). Wnt Ligands as a Part of the Stem Cell Niche in the Intestine and the Liver. Progress in molecular biology and translational science, 153, 1–19.
Unsal, E., Degirmenci, B., Harmanda, B., Erman, B., & Ozlu, N. (2016). A small molecule identified through an in silico screen inhibits Aurora B-INCENP interaction. Chemical biology & drug design, 88(6), 783–794.